Tolafentrine, a dual-selective phosphodiesterase 3/4 (PDE3/4) inhibitor, has been shown to have significant acute and chronic effects in a unilateral diacetamide-induced rat pulmonary hypertension model. Experiments show that long-term administration can significantly alleviate all unilateral bisacetamide-induced hemodynamic and gas exchange abnormalities, reduce right ventricular hypertrophy, and normalize pulmonary vascular remodeling changes[1].
Molecular Weight:
505.63
CAS Number:
[139308-65-9]
Formula:
C28H31N3O4S
Target:
Phosphodiesterase (PDE)
Application Notes:
MCE Product type: Reference compound
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