Harman-d3 is deuterium labeled Harmane. Harmane is a benzodiazepine receptor inhibitor (IC50=7 µM), with IC50 values for mACh, Opioid Receptor, MAO-A/B, and alpha2-adrenergic receptor of 24 µM, 2.8 µM, 0.5 µM, 5 µM, and 18 µM, respectively. Harmane also inhibits haloperidol and serotonin, with IC50 values of 163 µM and 101 µM, respectively. Harmane inhibits the I1 imidazoline receptor (IC50=30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF)[1][2][3][4][5][6].
Molecular Weight:
185.24
CAS Number:
[1216708-84-7]
Formula:
C12H7D3N2
Target:
Isotope-Labeled Compounds
Application Notes:
MCE Product type: Isotope-Labeled Compounds
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