DM-4103 is a major metabolite of Tolvaptan (HY-17000) that is metabolized primarily by the CYP3A4 enzyme in the liver. DM-4103 inhibits the ability of human liver transporters NTCP, BSEP, MRP2, MRP3, MRP4 (IC50 values are 16.3, 4.15, 51.0, 44.6, 4.26 µM, respectively) and bile acid transport in SCHH cells. DM-4103 can be used in the study of autosomal dominant polycystic kidney disease (ADPKD)[1][2].
Molecular Weight:
478.92
CAS Number:
[1346599-56-1]
Formula:
C26H23ClN2O5
Target:
P-glycoprotein
Application Notes:
MCE Product type: Reference compound
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