Migalastat-d5 (GR181413A-d5 (free base)) is deuterium labeled Migalastat. Migalastat (GR181413A free base) is an orally active alpha-galactosidase A molecular chaperone, with an IC50 value of 0.04 µM for human alpha-Gal A. Migalastat binds to the active site of certain unstable mutant forms of alpha-galactosidase A, facilitating their transport to the lysosome. After dissociation in the acidic environment, Migalastat enables the mutant alpha-galactosidase A to exhibit biological activity[1].
Molecular Weight:
168.20
Formula:
C6H8D5NO4
Target:
Glycosidase,Isotope-Labeled Compounds
Application Notes:
MCE Product type: Isotope-Labeled Compounds
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