18-Hydroxy-11-deoxy corticosterone, CAS [[379-68-0]]
Biozol Catalog Number:
MCE-HY-W738639
Supplier Catalog Number:
HY-W738639
Alternative Catalog Number:
MCE-HY-W738639-1UNIT,MCE-HY-W738639-1MG
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Alternative Names:
18-OH-DOC, 11-Deoxy-18-hydroxycorticosterone
18-Hydroxy-11-deoxy corticosterone (18-OH-DOC) is a mineralocorticoid whose synthesis is regulated by adrenocorticotropic hormone (ACTH) and angiotensin II. 18-Hydroxy-11-deoxy corticosterone is an intermediate in the metabolism of progesterone and plays an important role in regulating blood pressure and water-salt balance. Continuous infusion of 18-Hydroxy-11-deoxy corticosterone can increase systolic blood pressure in rats, and plasma levels of 18-Hydroxy-11-deoxy corticosterone are significantly elevated in the db/db mouse model of type 2 diabetes, suggesting its potential involvement in metabolic dysregulation and diabetes-related regulation. 18-Hydroxy-11-deoxy corticosterone holds promise for research in areas such as hypertension, diabetes, and other related fields[1].
