21-Deoxy Cortisone (21-Desoxycortisone, NSC 38722) is a corticosteroid metabolite of 11-ketoprogesterone. It is formed from 11-ketoprogesterone by the cytochrome P450 (CYP) isozyme CYP17A1, but can also be produced by oxidation of 21-deoxycortisone (HY-113405) by 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2). Congenital adrenal hyperplasia is an inborn error of metabolism characterized by a deficiency of 21-hydroxylase, and 21-Deoxy Cortisone levels are elevated in patients with congenital adrenal hyperplasia.
Molecular Weight:
344.44
Purity:
99.5
CAS Number:
[1882-82-2]
Formula:
C21H28O4
Target:
Endogenous Metabolite
Application Notes:
MCE Product type: Reference compound
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