Etoposide-d4 (VP-16-d4, VP-16-213-d4) is the deuterium labeled Etoposide (HY-13629). Etoposide (VP-16, VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy[1].