12(S)-HEPE is a monohydroxy fatty acid synthesized from EPA by the action of 12-LO. Unstimulated neutrophils metabolize 12(S)-HEPE to 12(S),20-diHEPE, whereas stimulated neutrophils produce 5(S),12(S)-HEPE via the 5-lipoxygenase pathway. The competitive action of 12(S)-HEPE with arachidonic acid as a substrate for 5-LO in the formation of leukotrienes may provide a basis for the anti-inflammatory potential of omega-3 fatty acids.
Molecular Weight:
318.45
CAS Number:
[116180-17-7]
Formula:
C20H30O3
Target:
Leukotriene Receptor,Lipoxygenase
Application Notes:
MCE Product type: Reference compound
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