Niraparib-d5 (MK-4827-d5) is the deuterium labeled Niraparib (HY-10619). Niraparib (MK-4827) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively. Niraparib leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity[1][2][3].
Molecular Weight:
325.42
Formula:
C19H15D5N4O
Target:
Apoptosis,Isotope-Labeled Compounds,PARP
Application Notes:
MCE Product type: Isotope-Labeled Compounds
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