D-alpha-Hydroxyglutaric acid-13C5 (disodium), CAS [[1648909-80-1]]

Product Overview

• Article Name: D-alpha-Hydroxyglutaric acid-13C5 (disodium), CAS [[1648909-80-1]]
• Biozol Catalog Number: MCE-HY-W779800
• Supplier Catalog Number: HY-W779800
• Alternative Catalog Number: MCE-HY-W779800-1MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

D-alpha-Hydroxyglutaric acid-13C5 disodium is the 13C-labeled D-alpha-Hydroxyglutaric acid (HY-113038). D-alpha-Hydroxyglutaric acid ((R)-2-Hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-alpha-Hydroxyglutaric acid is a weak competitive antagonist of alpha-ketoglutarate (alpha-KG) and inhibits multiple alpha-KG-dependent dioxygenases with a Ki of 10.87 mM. D-alpha-Hydroxyglutaric acid increases reactive oxygen species (ROS) production. D-alpha-Hydroxyglutaric acid binds and inhibits ATP synthase and inhibits mTOR signaling[1][2][3][4][5].

Product Properties

• Molecular Weight: 197.04
• CAS Number: [1648909-80-1]
• Formula: 13C5H6Na2O5
• Target: ATP Synthase,Endogenous Metabolite,Isotope-Labeled Compounds,mTOR,Reactive Oxygen Species (ROS)

Application Notes

• Application Notes: MCE Product type: Isotope-Labeled Compounds