CS790AM (Coppersensor 790 acetoxymethyl ester) is a cell-permeable, Cu+-targeted near-infrared fluorescent probe (lambdaabs=760 nm, lambdaem=790 nm) applicable to live cells. CS790AM can cross lipophilic cell membranes, and is converted into negatively charged CS790 under the action of intracellular esterases to be retained, thus enabling highly sensitive, reversible turn-on detection of labile Cu+ pools in live cells and mice. CS790AM possesses excellent biocompatibility and selectivity, avoids interference from other metal ions, shows no obvious toxicity, and can be rapidly cleared. CS790AM allows long-term longitudinal monitoring of individual mice, visualizes copper levels in internal organs and isolated livers, and effectively evaluates abnormal copper accumulation in Wilsons disease models (Atp7b-/-) as well as dynamic changes after chelator treatment. CS790AM can be used for research on Wilsons disease and related copper metabolic disorders[1][2][3].
Molecular Weight:
1105.27
CAS Number:
[1416808-87-1]
Formula:
C56H70BrN3O9S3
Target:
Fluorescent Dye
Application Notes:
MCE Product type: Dye Reagents
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