AMG-628 is an orally active inhibitor for TRPV1, that inhibits Capsaicin (HY-10448) or acid (pH 5)-induced Ca2+ influx into TRPV1- expressing CHO cell with IC50 of 4.9 and 3.1 nM. AMG-628 exhibits analgesic activity in Capsaicin (HY-10448)-induced rat model, and exhibits a half-life of 2.4 h in rats[1].
Molecular Weight:
492.57
CAS Number:
[862269-93-0]
Formula:
C25H25FN6O2S
Target:
TRP Channel
Application Notes:
MCE Product type: Reference compound
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