SMART1 is a highly specific and CRBN-dependent PROTAC that can effectively degrade Smurf1. SMART1 can block the PDK1-Akt signaling pathway in KRAS mutant colorectal cancer. SMART1 can inhibit tumor growth in KRAS mutant colorectal cancer (CRC) xenograft models.(Blue: CRBN ligand, Black: linker, Pink: Smurf1 ligand (Smurf1-L)) [1].
Molecular Weight:
753.76
Purity:
99.87
Formula:
C40H35N9O7
Target:
Akt,PDK-1,PROTACs
Application Notes:
MCE Product type: Reference compound
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