Sodium dichloroacetate is an orally active pyruvate dehydrogenase kinase (PDK) inhibitor. Sodium dichloroacetate also stimulates pyruvate dehydrogenase (PDH) activity and works as a Na+-K+-2Cl- cotransporter (NKCC) inhibitor. Sodium dichloroacetate prevents the phosphorylation of the E1alpha subunit of PDC, promoting the entry of pyruvate into the mitochondria for oxidative metabolism, reducing lactate production, and simultaneously increasing the production of reactive oxygen species (ROS). Sodium dichloroacetate inhibits tumor cell proliferation and induces apoptosis. Sodium dichloroacetate is promising for research of cancers[1][2].
Molecular Weight:
150.92
Purity:
99.78
CAS Number:
[2156-56-1]
Formula:
C2HCl2NaO2
Target:
Apoptosis,NKCC,PDHK,PDK-1,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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