Methoxyamine (O-Methylhydroxylamine) hydrochloride is an orally active and potent base excision repair (BER) inhibitor. Methoxyamine hydrochloride binds to 3 hydroxyl groups that are left behind by 3-methylpurine-DNA glycosylase (MPG) following excision of the damaged base and thus inhibits BER activity. Methoxyamine hydrochloride binds directly to the apyrimidinic (AP) sites. Methoxyamine hydrochloride synergistically enhances the therapeutic efficacy of DNA-damaging agents[1][2].
Molecular Weight:
83.52
Purity:
98
CAS Number:
[593-56-6]
Formula:
CH6ClNO
Target:
Apoptosis,DNA/RNA Synthesis
Application Notes:
Reference compound
* VAT and and shipping costs not included. Errors and price changes excepted