Recombinant Human CNTF Protein, Unconjugated
Catalog Number:
NBS-RBB-KGIHYT-100
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| Article Name: | Recombinant Human CNTF Protein, Unconjugated |
| Biozol Catalog Number: | NBS-RBB-KGIHYT-100 |
| Supplier Catalog Number: | RBB-KGIHYT-100 |
| Alternative Catalog Number: | NBS-RBB-KGIHYT-100 |
| Manufacturer: | Nordic BioSite |
| Category: | Proteine/Peptide |
| Species Reactivity: | Human |
| Conjugation: | Unconjugated |
| Ciliary Neurotrophic Factor (CNTF) is a cytokine belonging to the Interleukin 6 (IL-6) family, which also includes IL-6, Oncostatin M, Leukemia Inhibitory Factor (LIF), and Cardiotrophin-1. Structurally, CNTF resembles a four-helix bundle composition, similar to the other members of the IL-6 family. The receptor for CNTF is composed of three parts: a gp130-like subunit common in the IL-6 receptor family, a LIF Receptor beta subunit, and a CNTF specific alpha receptor subunit. Upon binding to the CNTF, the beta subunit of the CNTF receptorwill undergo tyrosine phosphorylation, and activate the Fixed JAK/STAT pathway. The main function of CNTF in vivo is to promote the differentiation and survival of a variety of neurons and glial cells, including sympathetic precursor cells and spinal motor neurons. Recombinant human Ciliary Neurotrophic Factor (rhCNTF) produced in E. coli is a single non-glycosylated polypeptide chain containing 199 amino acids. A fully biologically active molecule, rhCNTF has a molecular mass of 22.8 kDa analyzed by reducing SDS-PAGE. |
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