LILRB1 / ILT-2 / CD85j Antibody, IgG1, Clone: [VMP55], Mouse, Monoclonal
Catalog Number:
NBT-10859-MSM1-P1
- Images (0)
| Article Name: | LILRB1 / ILT-2 / CD85j Antibody, IgG1, Clone: [VMP55], Mouse, Monoclonal |
| Biozol Catalog Number: | NBT-10859-MSM1-P1 |
| Supplier Catalog Number: | 10859-MSM1-P1 |
| Alternative Catalog Number: | NBT-10859-MSM1-P1-100 |
| Manufacturer: | NeoBiotechnologies |
| Host: | Mouse |
| Category: | Antikörper |
| Application: | FC, IF, WB |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Hairy cell leukemia cells |
| Alternative Names: | CD85 antigen, CD85j antigen, Ig like transcript 2, immunoglobulin like transcript 2 (ILT2), leukocyte Ig like receptor 1, Leukocyte immunoglobulin like receptor 1, leukocyte immunoglobulin like receptor subfamily B member 1 soluble isoform, LILRB1, LIR1, Monocyte/macrophage immunoglobulin like receptor 7 (MIR7), PIRB |
| Leukocyte immunoglobulin-like receptors (LIRs) are members of the immunoglobulin superfamily of glycoproteins and are predominantly expressed by monocytes, B cells, dendritic cells, natural killer (NK) cells, peripheral blood leukocytes and tissues such as placenta, lung and liver. Immunoglobulin-like transcript 2 (ILT-2), also known as CD85 or MIR7, is a 650 amino acid glycoprotein that contains a 23 amino acid signal peptide, 4 extracellular C2-type IGSF domains and 4 intracellular ITIM motifs. ILT-2 can bind major histocompatability (MHC) class I molecules and inhibit cell termination by natural killer (NK) and T cells, and inhibit Ca2+ mobilization in myeloid cells triggered through the B cell antigen receptor and histocompatibility leukocyte antigens (HLA)-DR. ILT-2 contains four putative cytoplasmic tyrosine-based inhibitory motifs and upon tyrosine phosphorylation, associates with the tyrosine phosphatase SHP-1. |
Product Guarantee and Expert Support
