CD85 antigen, CD85j antigen, Ig like transcript 2, immunoglobulin like transcript 2 (ILT2), leukocyte Ig like receptor 1, Leukocyte immunoglobulin like receptor 1, leukocyte immunoglobulin like receptor subfamily B member 1 soluble isoform, LILRB1, LIR1, Monocyte/macrophage immunoglobulin like receptor 7 (MIR7), PIRB
Leukocyte immunoglobulin-like receptors (LIRs) are members of the immunoglobulin superfamily of glycoproteins and are predominantly expressed by monocytes, B cells, dendritic cells, natural killer (NK) cells, peripheral blood leukocytes and tissues such as placenta, lung and liver. Immunoglobulin-like transcript 2 (ILT-2), also known as CD85 or MIR7, is a 650 amino acid glycoprotein that contains a 23 amino acid signal peptide, 4 extracellular C2-type IGSF domains and 4 intracellular ITIM motifs. ILT-2 can bind major histocompatability (MHC) class I molecules and inhibit cell termination by natural killer (NK) and T cells, and inhibit Ca2+ mobilization in myeloid cells triggered through the B cell antigen receptor and histocompatibility leukocyte antigens (HLA)-DR. ILT-2 contains four putative cytoplasmic tyrosine-based inhibitory motifs and upon tyrosine phosphorylation, associates with the tyrosine phosphatase SHP-1.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Antibody Type:
Monoclonal Antibody
Application Notes:
Immunoprecipitation (1-2ug per 100-500ug of total protein (1ml of cell lysate)), Western Blot (1-2ug/ml), ,Flow Cytometry (1-2ug/million cells), Immunofluorescence (1-2ug/ml), ,Optimal dilution for a specific application should be determined.
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