Recombinant fragment (around aa1-200) of human IL22RA2 protein (exact sequence is proprietary)
Alternative Names:
IL 22BP, IL22RA2, Class II cytokine receptor, CRF2-10, CRF2-S1, CRF2X, Cytokine receptor class-II member 10, Cytokine receptor family type 2 soluble 1, IL-22 receptor subunit alpha-2, IL-22BP, IL-22R-alpha-2, Interleukin 22 binding protein, Interleukin 22 Receptor alpha 2, Class II cytokine receptor
IL-22R2 (Interleukin-22 receptor 2 chain), also known as IL-22 binding protein (IL-22BP), cytokine receptor family class II member 10 (CRF2-10) or CRF2- soluble 1 (CRF2-S1), is a soluble, nonsignaling single chain receptor for IL-22. It is highly expressed in intestine and lymph nodes and is also found in spleen, kidney and liver. IL-22R2 has a cytokine-binding domain that contains two FnIII domains. Its affinity for IL-22 is 4- to 10-fold higher than that of the membrane-bound IL-22 receptor, however it has a dissociation rate up to 20 times lower. By binding to IL-22, IL-22R2 prevents the binding to the IL-22 membrane-bound receptor and therefore inhibits IL-22 signaling. This suggests that IL-22R2 may be important in regulating inflammatory responses. In addition, IL-22R2 can be induced by lipopolysaccharides (LPSs).
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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