Topoisomerase I, Mitochondrial (TOP1MT) Antibody, IgG2b, Clone: [TOP1MT/488], Mouse, Monoclonal

Product Overview

• Article Name: Topoisomerase I, Mitochondrial (TOP1MT) Antibody, IgG2b, Clone: [TOP1MT/488], Mouse, Monoclonal
• Biozol Catalog Number: NBT-116447-MSM1-P1
• Supplier Catalog Number: 116447-MSM1-P1
• Alternative Catalog Number: NBT-116447-MSM1-P1-100
• Manufacturer: NeoBiotechnologies
• Host: Mouse
• Category: Antikörper
• Application: FC, IF, IHC, WB
• Species Reactivity: Human
• Immunogen: Recombinant full-length human TOP1MT protein
• Alternative Names: DNA topoisomerase I, TOP1MT, Topoisomerase I mitochondrial, Type IB Topoisomerase

Product Description

DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Due to their roles in DNA replication, recombination, and transcription, DNA topoisomerases have been identified as targets of numerous anticancer drugs. Mitochondrial Topo I (DNA topoisomerase I, mitochondrial) is a 601 amino acid protein that primarily acts to relieve DNA strain that may occur during duplication of mitochondrial DNA. As a type IB topoisomerase, mitochondrial Topo I requires a divalent metal, either, calcium or magnesium, as well as an alkaline pH for optimal activity.

Product Properties

• Clonality: Monoclonal
• Clone Designation: [TOP1MT/488]
• Molecular Weight: 70kDa
• Isotype: IgG2b
• NCBI: 116447
• UniProt: Q969P6
• Form: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.