Desmoglein-1 (DSG1) Antibody, IgG1, Clone: [18D4], Mouse, Monoclonal

Product Overview

• Article Name: Desmoglein-1 (DSG1) Antibody, IgG1, Clone: [18D4], Mouse, Monoclonal
• Biozol Catalog Number: NBT-1828-MSM1-P1
• Supplier Catalog Number: 1828-MSM1-P1
• Alternative Catalog Number: NBT-1828-MSM1-P1-100
• Manufacturer: NeoBiotechnologies
• Host: Mouse
• Category: Antikörper
• Application: FC, IF, WB
• Species Reactivity: Human
• Immunogen: Human desmoglein-1 intracellular domain
• Alternative Names: Cadherin family member 4, CDHF4, Desmoglein-1, Desmosomal glycoprotein 1, DG1, DSG1, EPKHE, EPKHIA, Pemphigus foliaceus antigen, PPKS1, SPPK1

Product Description

Recognizes a protein of ~150kDa, identified as Desmoglein-1 (DSG1). Desmoglein-1 is a member of the desmosomal cadherin family.Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms.Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is essential to epidermal integrity.

Product Properties

• Clonality: Monoclonal
• Clone Designation: [18D4]
• Molecular Weight: 150kDa (precursor), 160kDa (mature)
• Isotype: IgG1
• NCBI: 1828
• UniProt: Q02413
• Form: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Images

SDS-PAGE Analysis of Purified DSG1 Mouse Monoclonal Antibody (18D4). Confirmation of Integrity and Purity of Antibody