Desmoglein-3 (Squamous Cell Marker) Antibody, IgG1, Clone: [MSVA-543M], Mouse, Monoclonal

Product Overview

• Article Name: Desmoglein-3 (Squamous Cell Marker) Antibody, IgG1, Clone: [MSVA-543M], Mouse, Monoclonal
• Biozol Catalog Number: NBT-1830-MSM17-P0
• Supplier Catalog Number: 1830-MSM17-P0
• Alternative Catalog Number: NBT-1830-MSM17-P0-20
• Manufacturer: NeoBiotechnologies
• Host: Mouse
• Category: Antikörper
• Application: IHC
• Species Reactivity: Human
• Immunogen: Recombinant fragment (around aa 379-491) human DSG3 protein (exact sequence is proprietary)
• Alternative Names: 130kDa pemphigus vulgaris antigen (PVA), Balding (Bal), Cadherin family member 6 (CDHF6), Desmoglein-3 (DSG3)

Product Description

Recognizes a protein of 130kDa, identified as Desmoglein-3 (DSG3). This MAb is highly specific to Desmoglein-3 and does not cross-react with other members of the Desmoglein-family. DSG3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Research has shown that DSG3 has a very high sensitivity (80%) and specificity (100%) in recognizing squamous cell carcinoma (SqCC). Therefore, DSG3 is considered a very important marker for lung SqCC and can be a useful ancillary marker to separate SqCC from other subtypes of lung cancer. Moreover, studies have shown that DSG3 expression in lung SqCC may indicate a poor prognosis.

Product Properties

• Clonality: Monoclonal
• Clone Designation: [MSVA-543M]
• Molecular Weight: 130kDa
• Isotype: IgG1
• NCBI: 1830
• UniProt: P32926
• Form: Ab produced in HEK293 cell mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide.

Images

Desmoglein-3 Mouse Monoclonal Antibody (MSVA-543M) tested on many normal and cancer tissues. The immunohistochemistry staining in these tissues aligns with the expression data in Human Protein Atlas.