Recombinant E2F4 (Transcription Factor) Antibody, Clone: [E2F4/8645R], Rabbit, Monoclonal
Catalog Number:
NBT-1874-RBM18-P1ABX
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| Article Name: | Recombinant E2F4 (Transcription Factor) Antibody, Clone: [E2F4/8645R], Rabbit, Monoclonal |
| Biozol Catalog Number: | NBT-1874-RBM18-P1ABX |
| Supplier Catalog Number: | 1874-RBM18-P1ABX |
| Alternative Catalog Number: | NBT-1874-RBM18-P1ABX-100 |
| Manufacturer: | NeoBiotechnologies |
| Host: | Rabbit |
| Category: | Antikörper |
| Application: | IHC |
| Species Reactivity: | Human |
| Immunogen: | Recombinant fragment (around aa1-100) of human E2F4 protein (exact sequence is proprietary) |
| Alternative Names: | E2F transcription factor 4, E2F transcription factor 4 p107/p130 binding, E2F-4, p107/p130 binding protein |
| The human retinoblastoma gene product appears to play an important role in the negative regulation of cell proliferation. Functional inactivation of Rb can be mediated either through mutation or as a consequence of interaction with DNA tumor virus-encoded proteins. Of all the Rb associations described to date, the identification of a complex between Rb and the transcription factor E2F most directly implicates Rb in regulation of cell proliferation. E2F was originally identified through its role in transcriptional activation of the adenovirus E2 promoter. Sequences homologous to the E2F binding site have been found upstream of a number of genes that encode proteins with putative functions in the G1 and S phases of the cell cycle. E2F-1 is a member of a broader family of transcription regulators including E2F-2, E2F-3, E2F-4, E2F-5, E2F-6 and E2F-7 each of which forms heterodimers with a second protein, DP-1, forming an active E2F transcriptional regulatory complex. |
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