FCG10.1A / CD64 antibody was raised against rheumatoid synovial fluid cells and fibronectin purified human monocytes.
Alternative Names:
CD64, CD64A, CD64b, CD64c, Fc fragment of IgG, high affinity Ia, receptor (CD64), FCGR1, FCGR1A, FCGR1B, FCGR1C, FcRI, FcRIB, FCRIC, High affinity immunoglobulin gamma Fc receptor IB, IGFR1, IGFRB, IGFRC
Three different classes of IgG Fc receptors have been described: Fc A RI (CD64), Fc A RII (CD32) and Fc A RIII (CD16). The low affinity receptors, CD64 and CD16, have a putative role in mediating humoral immune responses. CD64 is a surface glycoprotein with high affinity for monomeric IgG, is expressed constitutively on monocytes and macrophages, and can be induced in neutrophils subsequent to IFN-A stimulation. CD64 plays a putative role in the initiation of cell-mediated cytotoxicity. Thus far, three genes encoding four distinct CD64 transcripts have been described. CD64 has been shown to associate with signal transducing subunit of the high affinity IgE receptor. Src family kinases Hck and Lyn show increased kinase activity and will co-immunoprecipitate with CD64 subsequent to receptor cross linking.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1mg/ml.
SDS-PAGE Analysis of Purified CD64 Mouse Monoclonal Antibody (FCGR1A/6887). Confirmation of Integrity and Purity of Antibody.
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