CD16 / FcgammaReceptor III Antibody, IgG2a, Clone: [HO-80], Mouse, Monoclonal

Product Overview

• Article Name: CD16 / FcgammaReceptor III Antibody, IgG2a, Clone: [HO-80], Mouse, Monoclonal
• Biozol Catalog Number: NBT-2214-MSM4-P1
• Supplier Catalog Number: 2214-MSM4-P1
• Alternative Catalog Number: NBT-2214-MSM4-P1-100
• Manufacturer: NeoBiotechnologies
• Host: Mouse
• Category: Antikörper
• Application: FC, Functional Studies, IF
• Species Reactivity: Human
• Immunogen: PBLs from a NK-leukemia patient
• Alternative Names: FcRIIIa, FCR-10, FcRIII, FCGRIII, FcR-10, Fc fragment of IgG, low affinity IIIa, receptor for (CD16), neutrophil-specific antigen NA, CD16a, low affinity immunoglobulin gamma Fc region receptor III-A, Fc-gamma RIIIa, immunoglobulin G Fc receptor III, Fc-gamma RIII-alpha, Fc-gamma receptor IIIb (CD16), CD16a antigen, Fc-gamma receptor III-2 (CD 16), FCGR3, Fc gamma receptor III-A, FCG3, low affinity III, receptor for (CD16), Fc-gamma RIII, IGFR3FcgammaRIIIA, CD16FCRIIIA, FCRIII, Fc fragment of IgG, low affinity IIIa, receptor (CD16a)

Product Description

It recognizes CD16 (FcgammaRIII), the low-affinity receptor for IgG with an apparent molecular weight of 50-80kDa. Two similar genes represent CD16, CD16A (FcgammaRIIIA), which exists as a hetero-oligomeric polypeptide-anchored form in macrophages and NK cells and CD16B (FcgammaRIIIB), which exist as a monomeric GPI-anchored form in neutrophils. Furthermore, there are two known polymorphisms of CD16B, NA-1 and NA-2. Individuals homozygous for NA-2 show a lower phagocytic capacity compared with NA-1. CD16 binds IgG in the form of immune complexes and shows preferential binding of IgG1 and IgG3 isotypes and minimal binding of IgG2 and IgG4. Upon IgG binding, both CD16 isoforms initiate signal transduction cascades that lead to a variety of responses including antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, degranulation and proliferation.

Product Properties

• Clonality: Monoclonal
• Clone Designation: [HO-80]
• Molecular Weight: 50-80kDa
• Isotype: IgG2a
• NCBI: 2214
• UniProt: P08637
• Form: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.