Recombinant fragment (around aa 38-165) of human FTL protein (exact sequence is proprietary)
Alternative Names:
Ferritin L chain, Ferritin L subunit, Ferritin light chain, Ferritin light polypeptide, FTL, LFTD, NBIA3
Mammalian ferritins consist of 24 subunits made up of 2 types of polypeptide chains, ferritin heavy chain and ferritin light chain. Ferritin heavy chains catalyze the first step in iron storage, the oxidation of Fe (II), whereas ferritin light chains promote the nucleation of ferrihydrite, enabling storage of Fe (III). Light chain ferritin is involved in cataracts by at least two mechanisms, hereditary hyperferritinemia cataract syndrome, in which light chain ferritin is overexpressed, and oxidative stress, an important factor in the development of ageing-related cataracts.
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Antibody Type:
Monoclonal Antibody
Application Notes:
Western Blot (1-2ug/ml),Immunohistochemistry (Formalin-fixed) (0.1-0.2ug/ml for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minu
SDS-PAGE Analysis Puri
Formalin-fixed, paraffin-embedded human Pancreas stained with Ferritin, Light Chain Monoclonal Antibody (FTL/1388).
Formalin-fixed, paraffin-embedded human Pancreas stained with Ferritin, Light Chain Monoclonal Antibody (FTL/1388).
SDS-PAGE Analysis Purified Ferritin, Light Chain Monoclonal Antibody (FTL/1388). Confirmation of Integrity and Purity of Antibody
Western Blot Analysis of human HeLa cell lysate using Ferritin, Light Chain Monoclonal Antibody (FTL/1388).
Analysis of Protein Array containing more than 19,000 full-length human proteins using Ferritin, Light Chain Mouse Monoclonal Antibody (FTL/1388) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD&apos,s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD&apos,s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Western Blot Analysis of human Kidney tissue lysate using Ferritin, Light Chain Monoclonal Antibody (FTL/1388).
Western blot analysis of Human Brain, Mouse Brain, Rat Brain, Human Lung, Mouse Lung, Rat Lung, Human Kidney, Mouse Kidney and Rat Kidney tissue lysates using Ferritin Light Chain Mouse Monoclonal Antibody (FTL/1388).
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