Recombinant fragment (around aa 50-250) of human GLUL protein (exact sequence is proprietary)
Alternative Names:
cell proliferation-inducing protein 59, GLUL, Glutamate ammonia ligase, GS, PIG43, PIG59, Glutamate decarboxylase, glutamine synthase, Glutamine synthetase, glutamine synthetase I, Proliferation inducing protein 43, GLNA, GLNS
Glutamine synthetase (Gl Syn) forms a homo-octamer that serves as a catalyst for the amination of glutamic acid to form glutamine. This enzyme is a marker for astrocytes, which serve as the primary site of conversion of glutamic acid to glutamine in the brain. Induction of glutamine synthetase is seen upon astrocyte cell contact with neurons. Elevated expression of glutamine synthetase in glial cells has been shown to protect neurons from degeneration due to excess glutamate. Glutamine synthetase is also present in the liver and is involved in nitrogen homeostasis. Overexpression of glutamine synthetase has been shown in primary liver cancers, indicating a potential role for glutamine synthetase in hepatocyte transformation.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Antibody Type:
Monoclonal Antibody
Application Notes:
Western Blot (1-2ug/ml),,Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 2
Western blot analysis of Y79 cell lysate using Glutamine S
Formalin-fixed, paraffin-embedded human liver stained with Glutamine Synthetase Mouse Monoclonal Antibody (GLUL/6604) at 2ug/ml. HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.
Western blot analysis of Y79 cell lysate using Glutamine Synthetase Mouse Monoclonal Antibody (GLUL/6604).
Western blot analysis of human liver tissue using Glutamine Synthetase Mouse Monoclonal Antibody (GLUL/6604).
SDS-PAGE Analysis of Purified Glutamine Synthetase Mouse Monoclonal Antibody (GLUL/6604). Confirmation of Purity and Integrity of Antibody.
Western blot analysis of Y79 cell lysate using Glutamine Synthetase Mouse Monoclonal Antibody (GLUL/6604).
Western blot analysis of Human Liver, Mouse Liver, Rat Liver, Human Brain, Mouse Brain and Rat Brain lysates using Glutamine Synthetase Mouse Monoclonal Antibody (GLUL/6604).
Western blot analysis of human liver lysate using Glutamine Synthetase Mouse Monoclonal Antibody (GLUL/6604).
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