Recombinant fragment (around aa 1-200) of human TBX21 protein (exact sequence is proprietary)
Alternative Names:
T box expressed in T cells, T box protein 21, T box transcription factor TBX21, T cell specific T box transcription factor T bet, T PET, T-cell-specific T-box transcription factor T-bet, TBET, TBLYM, TPET, Transcription factor TBLYM
T helper (Th) lymphocytes differentiate into two unique subsets, Th1 and Th2, which differ both in function and in the cytokines they secrete. Th1 and Th2 cytokines promote the growth and differentiation of their subset, and inhibit the growth and differentiation of the opposing subset. T-bet (T-box expressed in T cells) is a Th1-specific T-box transcription factor that controls the expression of the Th1 cytokine, IFN-g. T-bet also converts effector Th2 cells into the opposing Th1 subset. T-bet is selectively expressed in Th1 cells. The level of T-bet expression is increased by signals mediated by the T cell receptor (TCR). IL-12 also induces an increase in the level of T-bet. T-bet was originally isolated from nuclear extracts of resting and PMA/ionomycin-activated AE7 cells. It is expressed in low levels in AE7 cells, and in increased levels in stimulated AE7.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
IHC analysis of formalin-fixed, paraffin-embedded human colon carcinoma. T-bet / TBX21 Mouse Monoclonal Antibody (TBX21/6724). Inset: PBS instead of primary antibody, secondary only negative control.
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