HLA-A (MHC I) Antibody, IgG1, Clone: [108-2C5], Mouse, Monoclonal
Catalog Number:
NBT-3105-MSM3-P1
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| Article Name: | HLA-A (MHC I) Antibody, IgG1, Clone: [108-2C5], Mouse, Monoclonal |
| Biozol Catalog Number: | NBT-3105-MSM3-P1 |
| Supplier Catalog Number: | 3105-MSM3-P1 |
| Alternative Catalog Number: | NBT-3105-MSM3-P1-100 |
| Manufacturer: | NeoBiotechnologies |
| Host: | Mouse |
| Category: | Antikörper |
| Application: | FC, IF |
| Species Reactivity: | Human |
| Immunogen: | Normal human peripheral blood lymphocytes |
| Alternative Names: | HLA-A, HLA class 1A, MHC class I HLA-A |
| HLA-A, with HLA-B and HLA-C, belongs to major histocompatibility complex (MHC) class I antigens and expresses constitutively on all nucleated cells. MHC class I antigens play a role in class I MHC-associated antigen presentation, inhibition of NK cell cytotoxicity, tumor surveillance, and tissue allotransplantation. This MAb is useful for HLA molecular typing of peripheral blood leukocytes as well as a large number of leukemic cell lines. It reacts with an intralocus determinant present on a limited number of HLA-A locus-encoded gene products (HLA-A2, -A3, -A28, -A29, -A30, -A31 and -Aw33). Its epitope maps between aa65-to-aa80 of the 1 domain of the HLA-A. This MAb recognizes an intralocus determinant present on a limited number of HLA-A locus-encoded gene products (HLA-A2, -A3, A28, -A29, -A30, -A31 and -Aw33). Furthermore, by testing its reactivity with HLA-A2 natural variants and mutants, the importance of amino acid residues 79 and/or 80 of the alpha1 domain was demonstrated in the formation of an intralocus HLA-A determinant. |
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