HLA-E (Major histocompatibility complex, class I, E) Antibody, IgG2, Clone: [HLAE/9468], Mouse, Monoclonal

Product Overview

• Article Name: HLA-E (Major histocompatibility complex, class I, E) Antibody, IgG2, Clone: [HLAE/9468], Mouse, Monoclonal
• Biozol Catalog Number: NBT-3133-MSM2-P1ABX
• Supplier Catalog Number: 3133-MSM2-P1ABX
• Alternative Catalog Number: NBT-3133-MSM2-P1ABX-100
• Manufacturer: NeoBiotechnologies
• Host: Mouse
• Category: Antikörper
• Application: IHC
• Species Reactivity: Human
• Immunogen: Recombinant fragment (around aa1-150) of human HLAE protein (exact sequence is proprietary)
• Alternative Names: QA1, HLA-6.2

Product Description

HLA-E Antibody (3H2679) is an IgG1+ mouse monoclonal HLA-E antibody (also designated HLA major histocompatibility complex, class I, E antibody, human leukocyte antigen (HLA) E antibody, 45 kDa transmembrane class I human leukocyte antigen E antibody, chromosome 6p22 gene complex class 1E antibody, or natural killer cell (NK) expansion marker antibody) that detects the HLA-E protein of human origin by WB, IP, IF and IHC(P). HLA-E Antibody (3H2679) is available as the non-conjugated anti-HLA-E antibody. Major histocompatibility complex (MHC) molecules, which include human leukocyte antigens (HLAs), form an integral part of the immune response system. They are cell-surface receptors that bind foreign peptides and present them to cytotoxic T lymphocytes (CTLs). MHC class I molecules consist of two polypeptide chains, an a or heavy chain and a non-covalently associated protein, b-2-Microglobulin. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes. HLA-A is a MHC class I heavy chain molecule that plays a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. HLA-B and HLA-C are proteins encoded by closely related genes that also exist in the MHC class I. HLA-E belongs to the HLA class I heavy chain paralogs. HLA-E is a heterodimer consisting of a heavy chain and a light chain. The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules.

Product Properties

• Clonality: Monoclonal
• Clone Designation: [HLAE/9468]
• Molecular Weight: 40kDa
• Isotype: IgG2
• NCBI: 3133
• UniProt: P13747
• Form: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.