HLA-G (Major Histocompatibility Complex, class I, G) Antibody, IgG1, Clone: [HLAG/6686], Mouse, Monoclonal
Biozol Catalog Number:
NBT-3135-MSM1-P1ABX
Supplier Catalog Number:
3135-MSM1-P1ABX
Alternative Catalog Number:
NBT-3135-MSM1-P1ABX-100
Manufacturer:
NeoBiotechnologies
Host:
Mouse
Category:
Antikörper
Application:
IHC, WB
Species Reactivity:
Human
Immunogen:
Purified His-tagged HLA-G protein.
Alternative Names:
B2 microglobulin, DADB-15K14.8, HLA 6.0, HLA G histocompatibility antigen class I G, HLA G3, HLA60, HLAG, Major histocompatibility complex class I G, MHC class I antigen G, MHC G, T-cell A locus, TCA
Major histocompatibility complex (MHC), human leukocyte antigen (HLA) molecules are cell-surface receptors that bind foreign peptides and present them to T lymphocytes. MHC class I molecules consist of two polypeptide chains, an a or heavy chain, and a non-covalently associated protein, A°a2-microglobulin. Cytotoxic T lymphocytes bind antigenic peptides presented by MHC class I molecules. Antigens that bind to MHC class I molecules are typically 8-10 residues in length and are stabilized in a peptide binding groove. MHC class II molecules are encoded by polymorphic MHC genes and consist of a noncovalent complex of an a and b chain. Helper T lymphocytes bind antigenic peptides presented by MHC class II molecules. MHC class II molecules bind 13-18 amino acid antigenic peptides. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM and -DO molecules regulate binding of exogenous peptides to class II molecules (HLA-DR) by sustaining a conformation that favors peptide exchange. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Antibody Type:
Monoclonal Antibody
Application Notes:
Western Blot (1-2ug/ml),,Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20
Formalin-fixed, paraffin-embedded human tonsil stained with HLA-G Mou
Formalin-fixed, paraffin-embedded human prostate stained with HLA-G Mouse Monoclonal Antibody (HLAG/6686) at 2ug/ml. Inset: PBS instead of primary antibody, secondary negative control.
Formalin-fixed, paraffin-embedded human tonsil stained with HLA-G Mouse Monoclonal Antibody (HLAG/6686) at 2ug/ml.
Western blot analysis of Raji cell lysate using HLA-G Mouse Monoclonal Antibody (HLAG/6686).
Formalin-fixed, paraffin-embedded human tonsil stained with HLA-G Mouse Monoclonal Antibody (HLAG/6686) at 2ug/ml.
SDS-PAGE Analysis of Purified HLAG Mouse Monoclonal Antibody (HLAG/6686). Confirmation of Purity and Integrity of Antibody.
Western blot analysis of JEG-3 cell lysate using HLA-G Mouse Monoclonal Antibody (HLAG/6686).
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