MR1 / Major histocompatibility complex, class I-related Antibody, IgG2, Clone: [MR1/7579], Mouse, Monoclonal
Catalog Number:
NBT-3140-MSM3-P1
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| Article Name: | MR1 / Major histocompatibility complex, class I-related Antibody, IgG2, Clone: [MR1/7579], Mouse, Monoclonal |
| Biozol Catalog Number: | NBT-3140-MSM3-P1 |
| Supplier Catalog Number: | 3140-MSM3-P1 |
| Alternative Catalog Number: | NBT-3140-MSM3-P1-100 |
| Manufacturer: | NeoBiotechnologies |
| Host: | Mouse |
| Category: | Antikörper |
| Application: | IHC |
| Species Reactivity: | Human |
| Immunogen: | Recombinant fragment (around aa50-250) of human MR1 protein (exact sequence is proprietary) |
| Alternative Names: | Class I histocompatibility antigen like protein, HLALS, Major histocompatibility complex class I like sequence, Major histocompatibility complex class I related isoform CRA a, MHC class I related gene protein, MHC class I related protein 1 isoform B, MR1B, MR1C |
| MR1 (major histocompatibility complex, class I-related), also known as HLALS, is a 341 amino acid single-pass membrane protein that localizes to the endoplasmic reticulum, as well as to the extracellular side of the cell membrane, and contains one Ig-like C1-type domain. Expressed ubiquitously, MR1 exists as a heterodimer with b-2-Microglobulin and plays an important role in antigen presentation, specifically in the development and expansion of mucosalassociated invariant T cells (MAITs). MAITs are located in the gut and are involved in monitoring flora levels, as well as in conveying distress signals to other areas of the body, indicating a role for MR1 in proper digestion and immune system function. MR1 exists as four alternatively spliced isoforms and is encoded by a gene which maps to human chromosome 1. |
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