Recombinant Survivin / BIRC5 Antibody, Clone: [BIRC5/8987R], Rabbit, Monoclonal
Catalog Number:
NBT-332-RBM10-P0
- Images (0)
| Article Name: | Recombinant Survivin / BIRC5 Antibody, Clone: [BIRC5/8987R], Rabbit, Monoclonal |
| Biozol Catalog Number: | NBT-332-RBM10-P0 |
| Supplier Catalog Number: | 332-RBM10-P0 |
| Alternative Catalog Number: | NBT-332-RBM10-P0-20 |
| Manufacturer: | NeoBiotechnologies |
| Host: | Rabbit |
| Category: | Antikörper |
| Application: | IHC, WB |
| Species Reactivity: | Human |
| Immunogen: | Recombinant fragment (around aa1-100) of human BIRC5 protein (exact sequence is proprietary) |
| Alternative Names: | API4, Apoptosis inhibitor 4, Apoptosis inhibitor survivin, Baculoviral IAP repeat-containing protein 5, EPR 1, IAP4, Survivin variant 3 alpha, SVV, TIAP |
| The baculovirus protein p35 inhibits virally induced apoptosis of invertebrate and mammalian cells and may function to impair the clearing of virally infected cells by the host s immune system. This is accomplished at least in part by its ability to block both TNF- and FAS-mediated apoptosis through the inhibition of the ICE family of serine proteases. Two mammalian homologs of baculovirus p35, referred to as inhibitor of apoptosis protein (IAP) 1 and 2, share an amino terminal baculovirus IAP repeat (BIR) motif and a carboxy terminal RING finger. Although the c-IAPs do not directly associate with the TNF receptor (TNF-R), they efficiently block TNF-mediated apoptosis through their interaction with the downstream TNF-R effectors, TRAF1 and TRAF2. Additional IAP family members include ILP (for IAP-like protein) and survivin. ILP inhibits activated caspase-3, leading to the resistance of FAS-mediated apoptosis. Survivin (also designated TIAP) is expressed during the G2/M phase of the cell cycle and associates with microtubules of the mitotic spindle. Increased caspase-3 activity is detected when a disruption of survivin-microtubule interactions occurs. |
Product Guarantee and Expert Support
