HSP90AA1 (Heat Shock Protein 90) Antibody, IgG1, Clone: [HSP90AA1/7247], Mouse, Monoclonal
Catalog Number:
NBT-3320-MSM7-P1ABX
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| Article Name: | HSP90AA1 (Heat Shock Protein 90) Antibody, IgG1, Clone: [HSP90AA1/7247], Mouse, Monoclonal |
| Biozol Catalog Number: | NBT-3320-MSM7-P1ABX |
| Supplier Catalog Number: | 3320-MSM7-P1ABX |
| Alternative Catalog Number: | NBT-3320-MSM7-P1ABX-100 |
| Manufacturer: | NeoBiotechnologies |
| Host: | Mouse |
| Category: | Antikörper |
| Application: | IHC |
| Species Reactivity: | Human |
| Immunogen: | Recombinant fragment (around aa500-700) of human HSP90AA1 protein (exact sequence is proprietary) |
| Alternative Names: | Heat shock protein 90kDa alpha cytosolic class A member 1, Heat shock protein HSP 90 alpha, HSP 84, HSP 86, Hsp 90, HSP86, HSP90A, HSP90AA1, HSPC1, HSPC2, HSPCAL1, HSPCAL4, Renal carcinoma antigen NY-REN-38 |
| The heat shock response was first described for Drosophila salivary gland cells and morphologically consists of a change in their polytene chromosome puffing patterns that involves de novo synthesis of a few proteins. Similar heat shock proteins were later discovered in bacterial chicken and mammalian cells, and have been subsequently studied in other organisms. A series of proteins including HSP 90, HSP 70, HSP 20-30 and ubiquitin are induced by insults such as temperature shock, chemicals and other environmental stress. A major function of HSP 90 and other HSPs is to act as molecular chaperones. HSP 90 forms a complex with glucocorticoid receptor (GR), rendering the non ligand-bound receptor transcriptionally inactive. HSP 90 binds the GR as a heterocomplex composed of either HSP 56 or Cyclophilin D, forming an aporeceptor comiplex. HSP 90 also exists as a dimer with other proteins such as p60/sti1 and p23, forming an apo-receptor complex with estrogen and androgen receptors. |
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