Bence Jones Protein, BJP, IGLC 1/2/3, Mcg Marker, Paraprotein
This MAb is specific to lambda light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of Kappa to Lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the lambda light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkins lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.
Antibody purified from Bioreactor Concentrate by Protein A/G and conjugated to various reporter molecules. Prepared in 10mM PBS with 0.05% BSA and 0.05% azide.
Antibody Type:
Monoclonal Antibody
Application Notes:
Flow Cytometry (5ul per test per one million cells or 5ul per 100ul of whole blood),Immunofluorescence (1:50-1:100),Optimal dilution for a specific application should be determined.
Formalin-fixed, paraffin-embedded human Tonsil stained with Lambda Light Chain Monoclonal Antibody (LcN-2).
Western blot analysis of human Intestinal tissue lysate using Lambda Light Chain Monoclonal Antibody (LcN-2).
Confocal Immunofluorescent analysis of Ramos cells using AF488-labeled Lambda Light Chain Monoclonal Antibody (LcN-2) (Green). DAPI was used to stain the cell nuclei (blue).
Confocal Immunofluorescent analysis of Ramos cells using AF488-labeled Isotype Control MAb (IgG2a) (Green). DAPI was used to stain the cell nuclei (blue). (Negative Control)
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