CD123 is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudo-autosomal region on chromosomes X or Y.
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Formalin-fixed, paraffin-embedded human Tonsil stained with IL3RA/CD123 Mouse Monoclonal Antibody (IL3RA/1531).
Formalin-fixed, paraffin-embedded human Lymph Node stained with IL3RA/CD123 Mouse Monoclonal Antibody (IL3RA/1531).
Formalin-fixed, paraffin-embedded human Gastric Carcinoma stained with IL3RA/CD123 Mouse Monoclonal Antibody (IL3RA/1531).
SDS-PAGE Analysis Purified IL3RA/CD123 Mouse Monoclonal Antibody (IL3RA/1531). Confirmation of Integrity and Purity of Antibody.
Analysis of Protein Array containing >19,000 full-length human proteins using CD123 Mouse Monoclonal Antibody (IL3RA/1531) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD&apos,s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD&apos,s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Western blot analysis of Human Small Intestine and Human Gall Bladder tissue lysates using CD123 Recombinant Mouse Monoclonal Antibody (IL3RA/12850).
3563-MSM2-P0
Western blot analysis of Human Skin, Mouse Skin, Rat Skin, Hamster Skin and Guinea pig Skin tissue lysates using IL-3Ra Mouse Monoclonal Antibody (IL3RA/1822).
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