CD61 / Integrin 3 / Platelet Glycoprotein IIIa (Platelet Marker) Antibody, IgG2b, Clone: [ITGB3/2597], Mouse, Monoclonal

Product Overview

• Article Name: CD61 / Integrin 3 / Platelet Glycoprotein IIIa (Platelet Marker) Antibody, IgG2b, Clone: [ITGB3/2597], Mouse, Monoclonal
• Biozol Catalog Number: NBT-3690-MSM7-P1
• Supplier Catalog Number: 3690-MSM7-P1
• Alternative Catalog Number: NBT-3690-MSM7-P1-100
• Manufacturer: NeoBiotechnologies
• Host: Mouse
• Category: Antikörper
• Application: IHC
• Species Reactivity: Human
• Immunogen: Recombinant human ITGB3 protein fragment (aa 385-490) (exact sequence is proprietary)
• Alternative Names: BDPLT2, GP3A, GPIIIa, GT, HPA 1, HPA 4, Integrin beta-3, ITGB3, NAIT, Platelet fibrinogen receptor beta subunit, Platelet glycoprotein IIIa, PTP

Product Description

Reacts with human integrin beta3 (GPIIIa, vitronectin receptor beta chain). It associates with the IIb-chain (CD41) to form the GpIIb/GpIIIa complex (CD41/CD61).The CD41/CD61 complex appears early in megakaryocyte maturation. The activated CD41/CD61 complex is a receptor for von Willebrand factor, soluble fibrinogen, fibronectin, vitronectin and thrombospondin. It plays a central role in platelet activation and aggregation. The CD51/CD61 is implicated in tumor metastasis and adenoviral infection. The antibody detects platelets in smears of blood and bone marrow, as well as megakaryocytes in frozen sections and cell smears. The antibody is useful for classification of megakaryoblastic leukemia.

Product Properties

• Clonality: Monoclonal
• Clone Designation: [ITGB3/2597]
• Molecular Weight: 105kDa & 90kDa
• Isotype: IgG2b
• NCBI: 3690
• UniProt: P05106
• Form: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Images

Formalin-fixed, paraffin-embedded human Spleen stained with CD61 Mouse Monoclonal Antibody (ITGB3/2597).

SDS-PAGE Analysis of Purified CD61 Mouse Monoclonal Antibody (ITGB3/2597). Confirmation of Purity and Integrity of Antibody.