34/67kDa Laminin Receptor, 37kDa Laminin Receptor precursor, 37/67kDa Laminin Receptor, 37LRP, 40S Ribosomal Protein SA, 67kDa Laminin Receptor, 67LR, Colon Carcinoma Laminin-binding Protein, LAMBR, Laminin receptor 1, Laminin-binding Protein precursor p40, LAMR1, LBP/p40, LRP/LR, Multidrug resistance-associated protein MGr1-Ag, NEM/1CHD4, Ribosomal Protein SA (RPSA)
Laminins, a family of extracellular matrix glycoproteins, are the major non-collagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. Reportedly, level of laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1mg/ml.
Antibody Type:
Recombinant Monoclonal Antibody
Application Notes:
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal diluti
Formalin-fixed, paraffin-embedded human pancreasstained wit
Formalin-fixed, paraffin-embedded human pancreasstained with Laminin Receptor Recombinant Rabbit Monoclonal (RPSA/6332R). Inset: PBS instead of primary antibody, secondary only negative control.
Formalin-fixed, paraffin-embedded human pancreasstained with Laminin Receptor Recombinant Rabbit Monoclonal (RPSA/6332R). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.
Western Blot Analysis of Human Pancreas, Human Skin, Human Spleen, Human Stomach, HeLa and 3T3 lysates using Laminin Receptor Recombinant Rabbit Monoclonal Antibody (RPSA/6332R).
Western Blot Analysis of Pancreas, Skin and Spleen tissue lysates of different species using Laminin Receptor Recombinant Rabbit Monoclonal Antibody (RPSA/6332R).
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