DNA Ligase 1 Antibody, IgG1, Clone: [1A9], Mouse, Monoclonal

Product Overview

• Article Name: DNA Ligase 1 Antibody, IgG1, Clone: [1A9], Mouse, Monoclonal
• Biozol Catalog Number: NBT-3978-MSM1-P1
• Supplier Catalog Number: 3978-MSM1-P1
• Alternative Catalog Number: NBT-3978-MSM1-P1-100
• Manufacturer: NeoBiotechnologies
• Host: Mouse
• Category: Antikörper
• Application: ELISA, WB
• Species Reactivity: Bovine, Human, Mouse, Rat
• Immunogen: Full-length native cow LIG1 protein
• Alternative Names: DNA ligase 1, DNA ligase I, DNLI1_HUMAN, LIG 1, lig1, Ligase I DNA ATP dependent, MGC117397, MGC130025, Polydeoxyribonucleotide synthase [ATP] 1

Product Description

DNA Ligase I maintains the major DNA Ligase activity in proliferating cells by joining Okazaki fragments during lagging strand DNA replication. Human DNA Ligase I also has an essential role in DNA repair pathways, where it catalyzes the formation of phosphodiester bonds between adjacent 5 phosphoryl and 3 hydroxy termini at single breaks in duplex DNA molecules. In addition, DNA Ligase I plays a role in sealing nicks during excision repair. Similar to other DNA ligases, DNA Ligase I is built around a common catalytic core. Increased levels of DNA Ligase I are found in human tumors, as compared to benign tissues, as well as in peripheral blood lymphocytes. Furthermore, DNA Ligase I antisense ODNs syndrome (BS). Individuals with BS either have decreased levels of abnormally thermolabile DNA Ligase I or possess a dimeric form of this enzyme.

Product Properties

• Clonality: Monoclonal
• Clone Designation: [1A9]
• Molecular Weight: 133kDa
• Isotype: IgG1
• NCBI: 3978
• UniProt: P18858
• Form: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Images

SDS-PAGE Analysis of Purified DNA Ligase 1 Mouse Monoclonal Antibody (1A9). Confirmation of Purity and Integrity of Antibody.