CD91 / LDL Receptor Related Protein 1 (LRP1) Antibody, IgG1, Clone: [LRP1/6784], Mouse, Monoclonal

Product Overview

• Article Name: CD91 / LDL Receptor Related Protein 1 (LRP1) Antibody, IgG1, Clone: [LRP1/6784], Mouse, Monoclonal
• Biozol Catalog Number: NBT-4035-MSM1-P0
• Supplier Catalog Number: 4035-MSM1-P0
• Alternative Catalog Number: NBT-4035-MSM1-P0-20
• Manufacturer: NeoBiotechnologies
• Host: Mouse
• Category: Antikörper
• Application: IHC
• Species Reactivity: Human
• Immunogen: Recombinant fragment of human LRP1 protein (exact sequence is proprietary)
• Alternative Names: A2MR, Alpha 2 macroglobulin receptor, APOER, Apolipoprotein E receptor, IGFBP3R, Low-density lipoprotein receptor-related protein 1 intracellular domain, LRP-1, LRP-515, LRP-85, Lrp1, LRP1 protein, Prolow density lipoprotein receptor related protein 1, TbetaRV/LRP1/IGFBP3 receptor, TGFBR5, Type V tgf beta receptor

Product Description

Members of the LDL receptor gene family, including LDLR (low density lipoprotein receptor), LEP1 (low density lipoprotein related protein), megalin (also designated GP330), VLDLR (very low density lipoprotein receptor) and apoER2 are characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. LRP1, also designated LRP and -2-Macroglobulin receptor, is an endocytic receptor that mediates the uptake of at least 15 ligands, including -2-Macroglobulin and apoE. LRP1 is cleaved into a membrane subunit and an extracellular subunit, which remain non-covalently associated. Proper folding and trafficking of LRP1 is facilitated by the receptor-associated protein (RAP), a molecular chaperone. The uptake of all known ligands through LRP1 can be blocked by RAP, which induces a conformational change in the receptor that renders it unable to bind ligands. LRP1, which is expressed in brain, liver and lung, is also implicated in Alzheimer s disease (AD), as the human LRP gene localizes to a potential AD locus on chromosome 12.

Product Properties

• Clonality: Monoclonal
• Clone Designation: [LRP1/6784]
• Molecular Weight: 85/515/600kDa
• Isotype: IgG1
• NCBI: 4035
• UniProt: Q07954
• Form: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Images

Formalin-fixed, paraffin-embedded human lung stained with CD91 / LRP1 Mouse Monoclonal Antibody (LRP1/6784) Inset: PBS instead of primary antibody, secondary only negative control.