TACSTD2 is a cell surface glycoprotein receptor. It is a single pass type I membrane protein containing one thyroglobulin type-1 domain, an epidermal growth factor-like repeat, a phosphatidylinositol binding site and tyrosine phosphorylation sites near the C-terminus. It plays a role in transducing intracellular calcium signals. It is expressed in trophoblast cells, cornea and multi-stratified epithelia. It is also highly expressed in several types of tumors and is involved in regulating the growth of carcinoma cells.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Antibody Type:
Monoclonal Antibody
Application Notes:
Immunofluorescence (1-2ug/ml), Western Blot (1-2ug/ml), Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C
Formalin-fixed, paraffin-embedded human colon carcinoma stained with TACSTD2 / TROP2 Mouse Monoclonal Antibody (TACSTD2/2152).
Formalin-fixed, paraffin-embedded human pancreatic carcinoma stained with TACSTD2 / TROP2 Mouse Monoclonal Antibody (TACSTD2/2152).
Formalin-fixed, paraffin-embedded human pancreatic carcinoma stained with TACSTD2 / TROP2 Mouse Monoclonal Antibody (TACSTD2/2152).
SDS-PAGE Analysis Purified TACSTD2 / TROP2 Mouse Monoclonal Antibody (TACSTD2/2152). Confirmation of Integrity and Purity of Antibody.
Confocal immunofluorescence of MeOH-fixed MCF-7 cells. TACSTD2 / TROP2 Mouse Monoclonal Antibody (TACSTD2/2152) labeled with CF488 (green), RedDot is used to label the nuclei.
Analysis of Protein Array containing >19,000 full-length human proteins using TACSTD2 Mouse Monoclonal Antibody (TACSTD2/2152) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD&apos,s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD&apos,s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Western blot analysis of Human skin and A-431 lysates using TACSTD2 / TROP2 (Epithelial Marker) Mouse Monoclonal Antibody (TACSTD2/2152).
Western blot analysis of Human skin, Mouse skin, Rat skin, Hamster skin, Guinea pig skin and Rabbit skin tissue lysates using TACSTD2 / TROP2 (Epithelial Marker) Mouse Monoclonal Antibody (TACSTD2/2152).
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