MAGE-1 (Target for Cancer Immunotherapy) Antibody, IgG1, Clone: [MA454], Mouse, Monoclonal

Product Overview

• Article Name: MAGE-1 (Target for Cancer Immunotherapy) Antibody, IgG1, Clone: [MA454], Mouse, Monoclonal
• Biozol Catalog Number: NBT-4100-MSM1-P0
• Supplier Catalog Number: 4100-MSM1-P0
• Alternative Catalog Number: NBT-4100-MSM1-P0-20,NBT-4100-MSM1-P0-100
• Manufacturer: NeoBiotechnologies
• Host: Mouse
• Category: Antikörper
• Application: IHC
• Species Reactivity: Canine, Human, Rat
• Immunogen: Recombinant full-length human MAGE-A1 protein
• Alternative Names: MZ2 E, cancer/testis antigen 1.1, CT1.1, MAGE1A, MAGEA1, Melanoma antigen family A 1, Melanoma associated antigen 1, Melanoma associated antigen MZ2 E

Product Description

Recognizes a protein of 42-46kDa, identified as MAGE-1. This MAb does not cross-react with MAGE-2, -3, -4, -6 -9, -10, -or -12 protein. Human malignant neoplasms carry rejection antigens that are recognized by the patients autologous, tumor directed and specific, cytolytic, CD8+ T lymphocyte clones (CTL). The MAGE family of genes codes an important group of antigens. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs). Because MAGE-1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on normal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy.

Product Properties

• Clonality: Monoclonal
• Clone Designation: [MA454]
• Molecular Weight: 42-46kDa
• Isotype: IgG1
• NCBI: 4100
• UniProt: P43355
• Form: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Antibody Type: Monoclonal Antibody

Application Notes

• Application Notes: Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minutes), Optimal dilution f

Images

Formalin-fixed, paraffin-embedded human Testicular Carcinoma stained with MAGE-1 Mouse Monoclonal Antibody (MA454).

SDS-PAGE Analysis of Purified MAGE-1 Mouse Monoclonal Antibody (MA454). Confirmation of Integrity and Purity of Antibody