Recombinant fragment (aa 650-750) of human MCM3 protein (exact sequence is proprietary)
Alternative Names:
Cervical cancer proto-oncogene 5, DNA polymerase alpha holoenzyme-associated protein P1, DNA replication factor MCM3, DNA replication licensing factor mcm3, HCC5, hRlf beta subunit, Human cervical cancer proto oncogene 5, MGC1157, Minichromosome maintenance complex component 3, Minichromosome maintenance deficient 3, P102 protein, Replication licensing factor beta subunit, RLF beta subunit, RLF subunit beta
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for once per cell cycle DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation.
Ab produced in CHO cell mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide.
DNA replication licensing factor MCM3 Mouse Monoclonal Antibody (MSVA-503M) tested on many normal and cancer tissues. The immunohistochemistry staining in these tissues aligns with the expression data in Human Protein Atlas.
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