MMP2 / Collagenase Type IV A (Tumor Metastasis Marker) Antibody, IgG1, Clone: [4D3], Mouse, Monoclonal

Product Overview

• Article Name: MMP2 / Collagenase Type IV A (Tumor Metastasis Marker) Antibody, IgG1, Clone: [4D3], Mouse, Monoclonal
• Biozol Catalog Number: NBT-4313-MSM4-P1
• Supplier Catalog Number: 4313-MSM4-P1
• Alternative Catalog Number: NBT-4313-MSM4-P1-100
• Manufacturer: NeoBiotechnologies
• Host: Mouse
• Category: Antikörper
• Application: IHC
• Species Reactivity: Human
• Immunogen: Recombinant human MMP2 protein fragment (aa557-569)
• Alternative Names: 72kD type IV collagenase, CLG4A, Collagenase Type 4 alpha, Collagenase type IV A, Gelatinase A, Gelatinase alpha, Gelatinase neutrophil, Matrix metalloproteinase-2, MMP2, MONA, Neutrophil gelatinase, PEX, TBE-1

Product Description

It recognizes a protein of 72kDa, which is identified as MMP2. The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, Fibronectin, Laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-2 (also designated type IV collagenase) cleaves collagen types IV,V, VII and X and gelatin type I. Activation of MMP-2 secretion requires the Ras signaling pathway.

Product Properties

• Clonality: Monoclonal
• Clone Designation: [4D3]
• Molecular Weight: 72kDa (Pro), 63kDa (cleaved)
• Isotype: IgG1
• NCBI: 4313
• UniProt: P08253
• Form: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Images

SDS-PAGE Analysis of Purified MMP2 Mouse Monoclonal Antibody (4D3). Confirmation of Integrity and Purity of Antibody.