PAPP-A / Pappalysin-1 (Marker of Atherosclerosis and Aneuploid Fetus) Antibody, IgG2b, Clone: [MSVA-780M], Mouse, Monoclonal

Product Overview

• Article Name: PAPP-A / Pappalysin-1 (Marker of Atherosclerosis and Aneuploid Fetus) Antibody, IgG2b, Clone: [MSVA-780M], Mouse, Monoclonal
• Biozol Catalog Number: NBT-5069-MSM17-P0
• Supplier Catalog Number: 5069-MSM17-P0
• Alternative Catalog Number: NBT-5069-MSM17-P0-20
• Manufacturer: NeoBiotechnologies
• Host: Mouse
• Category: Antikörper
• Application: IHC
• Species Reactivity: Human
• Immunogen: Recombinant fragment (within aa 351-523) of human PAPP-A protein (exact sequence is proprietary)
• Alternative Names: ASBABP2, Aspecific BCL2 ARE binding protein 2, Differentially placenta 1 expressed protein, DIPLA1, IGF-dependent, IGFBP4ase, Insulin-like growth factor-dependent IGF-binding protein 4 protease (IGFBP-4 protease), PAPA, PAPP A, PAPPA1, Pappalysin-1, Pregnancy Associated Plasma Protein A (PAPP-A)

Product Description

Pregnancy Associated Plasma Protein (PAPP-A) is found in maternal blood that increases as pregnancy progresses, although it is not specific to pregnancy. It is principally expressed in the syncytiotrophoblast of the placenta, which forms the main source of circulating maternal PAPP-A. It cleaves insulin-like growth factor binding proteins (IGFBPs), IGFBP-4 and IGFBP-5. IGFBP-4 cleavage is enhanced significantly in the presence of bound IGF, whereas IGFBP-5 cleavage is inhibited slightly by IGF presence. It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. PAPPA has also been suggested as a potential biomarker of acute myocardial infarction and Coronary Artery Disease (CAD).

Product Properties

• Clonality: Monoclonal
• Clone Designation: [MSVA-780M]
• Molecular Weight: 181kDa
• Isotype: IgG2b
• NCBI: 5069
• UniProt: Q13219
• Form: Ab produced in CHO cell mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide.

Images

Pappalysin-1 Mouse Monoclonal Antibody (MSVA-780M) tested on many normal and cancer tissues. The immunohistochemistry staining in these tissues aligns with the expression data in Human Protein Atlas.