Recombinant fragment (around aa1-200) of human PAX4 protein (exact sequence is proprietary)
Alternative Names:
KPD, MODY9, Paired box 4
Pax-4 (paired box gene 4) protein influences normal differentiation of Insulinproducing cells and influences normal pancreatic islet development. Pax-4 protein is a transcriptional repressor that binds to a common cis element in the Glucagon, Insulin and Somatostatin promoters. Mouse Pax-4 transcript is present in pancreatic islets, and the islet cell lines MIN6, TC and NIT1. Differentiation of endoderm-derived endocrine pancreas is mediated through Pax-4 and Pax-6. Pax-4 may act as a Pax-6 repressor due to the competition for binding sites and lower transactivation potential of Pax-4. The human Pax-4 gene encodes a deduced 350 amino acid protein that is 80% identical to the deduced mouse Pax-4 protein.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
SDS-PAGE Analysis of Purified PAX4 Mouse Monoclonal Antibody (PAX4/3011). Confirmation of Purity and Integrity of Antibody.
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