Recombinant fragment (around aa300-600) of human ENPP3 protein (exact sequence is proprietary)
Alternative Names:
B10, NPP3, PDNP3, CD203c, PD-IBETA
Ecto-nucleotide pyrophosphatase/phosphodiesterase-I enzymes (E-NPP), a group of type II transmembrane proteins, cleave phosphodiester and phosphosulfate bonds in deoxynucleotides, NAD, and nucleotide sugars. There exist three closely related proteins in mammalian species: E-NPP1 (PC-1), E-NPP2 (PDNP2), and E-NPP-3, also known as CD203c, each expressed in different cells or at different locations in the same cells. Basophils, a type of major proinflammatory effector cells involved in diverse pathologic reactions, exhibit CD203c expression. For instance, CD203c expression increases in response to a variety of allergens, including cat dander, latex, and bee and wasp venom. Hovever, these allergies are not the only condition associated with CD203c upregulation, CD203c upregulation may also serve as a tumor marker for colon carcinoma.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
SDS-PAGE Analysis of Purified CD203c Mouse Monoclonal Antibody (ENPP3/9892). Confirmation of Purity and Integrity of Antibody.
Formalin-fixed, paraffin-embedded human kidney stained with CD203c / ENPP3 Mouse Monoclonal Antibody (ENPP3/9892). Inset: PBS instead of primary antibody, secondary only negative control.
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