Recombinant ATRX / RAD54 (Alpha Thalassemia Mental Retardation) Antibody, IgG1, Clone: [rATRX/3446], Mouse, Monoclonal

Product Overview

• Article Name: Recombinant ATRX / RAD54 (Alpha Thalassemia Mental Retardation) Antibody, IgG1, Clone: [rATRX/3446], Mouse, Monoclonal
• Biozol Catalog Number: NBT-546-MSM5-P1
• Supplier Catalog Number: 546-MSM5-P1
• Alternative Catalog Number: NBT-546-MSM5-P1-100
• Manufacturer: NeoBiotechnologies
• Host: Mouse
• Category: Antikörper
• Application: IHC
• Species Reactivity: Human
• Immunogen: Recombinant full-length human ATRX protein
• Alternative Names: Alpha thalassemia/mental retardation syndrome X linked homolog, ATP-dependent helicase ATRX, ATR2, ATRX, DNA-dependent ATPase and helicase, MRXHF1, RAD54, RAD54L, SFM1, SHS, Transcriptional regulator ATRX, X-linked helicase II, X-linked nuclear protein, XH2, XNP, Znf-HX

Product Description

ATRX is a member of the Snf2 family of helicase/ATPases, which contribute to the remodeling of the nucelosome structure in an ATP-dependent manner, and facilitate the initiation of transcription and replication. Structurally, ATRX contains a PHD zinc finger motif. ATRX is regulated throughout the cell cycle where it is differentially distributed within the nucleus. During interphase, ATRX predominately associates with the nuclear matrix, while during mitosis, ATRX localizes with condensed chromatin. At the onset of M phase, phosphorylation rapidly induces this redistribution of ATRX to the short arms of human acrocentric chromosomes, where it then specifically complexes with heterochromatin protein 1 (TM) to mediate chromosomal segregation. Mutations in the ATRX gene correlate with a high incidence of severe X-linked form of syndromal mental retardation associated with (TM) thalassemia or ATRX syndrome

Product Properties

• Clonality: Monoclonal
• Clone Designation: [rATRX/3446]
• Molecular Weight: 280kDa
• Isotype: IgG1
• NCBI: 546
• UniProt: P46100
• Form: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Images

Formalin-fixed, paraffin-embedded human glioma stained with ATRX Recombinant Mouse Monoclonal Antibody (rATRX/3446).

SDS-PAGE Analysis of Purified ATRX Recombinant Mouse Monoclonal Antibody (rATRX/3446). Confirmation of Integrity and Purity of Antibody.

Formalin-fixed, paraffin-embedded human prostate stained with ATRX Recombinant Mouse Monoclonal Antibody (rATRX/3446).