PMEPA1 (prostate transmembrane protein, androgen induced 1 is a 287 amino acid single-pass membrane protein that contains WW-binding motifs and localizes to the cell membrane. Expressed at high levels in prostate, kidney and ovary, PMEPA1 interacts with NEDD4 and may play a role in regulating AR (androgen receptor) levels, specifically in prostate cells. Down regulation of PMEPA1 is observed in prostate tumors, suggesting that PMEPA1 may exhibit activity as a tumor suppressor. Overexpression of this protein may play a role in multiple types of cancer.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Antibody Type:
Recombinant Monoclonal Antibody
Application Notes:
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes),Optimal dilutio
Formalin-fixed, paraffin-embedded human colon carcinoma stained with PMEPA1 Recombinant Mouse Monoclonal (rPMEPA1/6422).
Formalin-fixed, paraffin-embedded human prostate stained with PMEPA1 Recombinant Mouse Monoclonal (rPMEPA1/6422).
SDS-PAGE Analysis of Purified PMEPA1 Recombinant Mouse Monoclonal (rPMEPA1/6422). Confirmation of Purity and Integrity of Antibody.
Western Blot Analysis of HeLa cell lysate using PMEPA1 / TMEPAI Recombinant Mouse Monoclonal Antibody (r-+-u-i-+-e1/6422).
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