Recombinant full-length human CCAR2 / KIAA1967 protein
Alternative Names:
CCAR2, Cell division cycle and apoptosis regulator protein 2, DBC.1, DBC1, DBIRD complex subunit KIAA1967, Deleted in breast cancer gene 1 protein, K1967_HUMAN, KIAA1967, NET35, p30 DBC, p30DBC
DBC-1 (deleted in breast cancer gene 1 protein), also known as p30 DBC protein, is one of the genes located within the region of chromosome 8p21.3 that is homozygously deleted in some breast cancers. DBC-1 contains a nuclear localization signal, an N-terminal leucine zipper, an EF hand and a C-terminal coiled-coil region. DBC-1 is closely related to DIS but lacks the SAP domain. During death signaling mediated by TNF, endogenous DBC-1 undergoes caspase-dependent processing to generate DBC-1 p120 and p66, both of which include the C-terminus of the protein. Both DBC-1 p120 and p66 relocate to the cytoplasm. Overexpression of the DBC-1 p120 form results in mitochondrial clustering and matrix condensation and increases the sensitivity of cells to TNF-mediated apoptosis. In addition, DBC-1 directly interacts with unliganded ER, stabilizing its expression and therefore collaborating to suppress apoptosis and promote hormone-independent cell growth.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
SDS-PAGE Analysis of Purified KIAA1967 Mouse Monoclonal Antibody (PCRP-KIAA1967-1D10). Confirmation of Purity and Integrity of Antibody.
Flow Cytometric Analysis of PFA-fixed HeLa cells. KIAA1967 Mouse Monoclonal Antibody (PCRP-KIAA1967-1D10) followed by goat anti-mouse IgG-CF488 (blue), unstained cells (red).
Analysis of Protein Array containing more than 19,000 full-length human proteins using KIAA1967 Mouse Monoclonal Antibody (PCRP-KIAA1967-1D10). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SDs) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SDs) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
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